View source for 6coe


==AtHNL enantioselectivity mutant At-A9-H7 Apo Y13C,Y121L,P126F,L128W,C131T,F179L,A209I with benzaldehyde, MANDELIC ACID NITRILE==
<StructureSection load='6coe' size='340' side='right'caption='[[6coe]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6coe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6COE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6COE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=MNN:(S)-MANDELIC+ACID+NITRILE'>MNN</scene>, <scene name='pdbligand=MXN:(2R)-HYDROXY(PHENYL)ETHANENITRILE'>MXN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HNL, MES5, At5g10300, F18D22_70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(R)-mandelonitrile_lyase (R)-mandelonitrile lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.10 4.1.2.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6coe OCA], [http://pdbe.org/6coe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6coe RCSB], [http://www.ebi.ac.uk/pdbsum/6coe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6coe ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HNL_ARATH HNL_ARATH]] Involved in cyanogenesis, the release of HCN from injured tissues (By similarity). Displays R-selective hydroxynitrile lyase activity. Also accepts nitromethane (MeNO2) as a donor in a reaction with aromatic aldehydes to yield (R)-beta-nitro alcohols.<ref>PMID:18467465</ref> <ref>PMID:19433222</ref> <ref>PMID:21439333</ref> <ref>PMID:17907254</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arath]]
[[Category: Large Structures]]
[[Category: Desrouleaux, R]]
[[Category: Jones, B J]]
[[Category: Kazlauskas, R J]]
[[Category: Alpha beta hydrolase globular hydroxynitrile lyase]]
[[Category: Lyase]]