View source for 6fcn


==Crystal structure of human PCNA soaked with p47phox(106-127) peptide==
<StructureSection load='6fcn' size='340' side='right' caption='[[6fcn]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6fcn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FCN FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1axc|1axc]], [[6fcm|6fcm]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fcn OCA], [http://pdbe.org/6fcn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fcn RCSB], [http://www.ebi.ac.uk/pdbsum/6fcn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fcn ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN]] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Frachet, P]]
[[Category: Housset, D]]
[[Category: Nuclear protein]]
[[Category: Proliferating cell nuclear antigen]]