View source for 6he7


==20S proteasome from Archaeoglobus fulgidus==
<StructureSection load='6he7' size='340' side='right' caption='[[6he7]], [[Resolution|resolution]] 3.69&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6he7]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfu Arcfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HE7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">psmA, AF_0490 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 ARCFU]), psmB, AF_0481 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 ARCFU])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6he7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6he7 OCA], [http://pdbe.org/6he7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6he7 RCSB], [http://www.ebi.ac.uk/pdbsum/6he7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6he7 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PSA_ARCFU PSA_ARCFU]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity).[HAMAP-Rule:MF_00289_A] [[http://www.uniprot.org/uniprot/PSB_ARCFU PSB_ARCFU]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity).[HAMAP-Rule:MF_02113_A] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Proteasomes occur in all three domains of life, and are the principal molecular machines for the regulated degradation of intracellular proteins. They play key roles in the maintenance of protein homeostasis, and control vital cellular processes. While the eukaryotic 26S proteasome is extensively characterized, its putative evolutionary precursor, the archaeal proteasome, remains poorly understood. The primordial archaeal proteasome consists of a 20S proteolytic core particle (CP), and an AAA-ATPase module. This minimal complex degrades protein unassisted by non-ATPase subunits that are present in a 26S proteasome regulatory particle (RP). Using cryo-EM single-particle analysis, we determined structures of the archaeal CP in complex with the AAA-ATPase PAN (proteasome-activating nucleotidase). Five conformational states were identified, elucidating the functional cycle of PAN, and its interaction with the CP. Coexisting nucleotide states, and correlated intersubunit signaling features, coordinate rotation of the PAN-ATPase staircase, and allosterically regulate N-domain motions and CP gate opening. These findings reveal the structural basis for a sequential around-the-ring ATPase cycle, which is likely conserved in AAA-ATPases.

Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle.,Majumder P, Rudack T, Beck F, Danev R, Pfeifer G, Nagy I, Baumeister W Proc Natl Acad Sci U S A. 2018 Dec 17. pii: 1817752116. doi:, 10.1073/pnas.1817752116. PMID:30559193<ref>PMID:30559193</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6he7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arcfu]]
[[Category: Proteasome endopeptidase complex]]
[[Category: Baumeister, W]]
[[Category: Beck, F]]
[[Category: Majumder, P]]
[[Category: Rudack, T]]
[[Category: Aaa-atpase]]
[[Category: Archaea]]
[[Category: Hydrolase]]
[[Category: Pan]]
[[Category: Proteasome]]