View source for 3jb8


==Insight into Three-dimensional structure of Maize Chlorotic Mottle Virus Revealed by Single Particle Analysis==
<StructureSection load='3jb8' size='340' side='right' caption='[[3jb8]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3jb8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Maize_chlorotic_mottle_virus Maize chlorotic mottle virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JB8 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jb8 OCA], [http://pdbe.org/3jb8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jb8 RCSB], [http://www.ebi.ac.uk/pdbsum/3jb8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jb8 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Maize chlorotic mottle virus (MCMV) is the only member of the Machlomovirus genus in the family Tombusviridae. Here, we obtained the Cryo-EM structure of MCMV by single particle analysis with most local resolution at approximately 4 A. The Calpha backbone was built based on residues with bulky side chains. The resolved C-terminus of the capsid protein subunit and obvious openings at the 2-fold axis demonstrated the compactness of the asymmetric unit, which indicates an important role in the stability of MCMV. The Asp116 residue from each subunit around the 5-fold and 3-fold axes contributed to the negative charges in the centers of the pentamers and hexamers, which might serve as a solid barrier against the leakage of genomic RNA. Finally, the loops most exposed on the surface were analyzed and are proposed to be potential functional sites related to MCMV transmission.

Insight into the three-dimensional structure of maize chlorotic mottle virus revealed by Cryo-EM single particle analysis.,Wang CY, Zhang QF, Gao YZ, Zhou XP, Ji G, Huang XJ, Hong J, Zhang CX Virology. 2015 Nov;485:171-8. doi: 10.1016/j.virol.2015.07.014. Epub 2015 Aug 11. PMID:26275511<ref>PMID:26275511</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
*[[Virus coat protein|Virus coat protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Maize chlorotic mottle virus]]
[[Category: Gao, Y Z]]
[[Category: Hong, J]]
[[Category: Huang, X J]]
[[Category: Ji, G]]
[[Category: Wang, C Y]]
[[Category: Zhang, C X]]
[[Category: Zhang, Q F]]
[[Category: Zhou, X P]]
[[Category: Icosahedral virus]]
[[Category: Mcmv]]
[[Category: Single particle analysis]]
[[Category: Three-dimensional structure]]
[[Category: Transmission]]
[[Category: Virus]]