View source for 3bta

[[Image:3bta.gif|left|200px]]

 {{Structure
|PDB= 3bta |SIZE=350|CAPTION= <scene name='initialview01'>3bta</scene>, resolution 3.2&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span>
|GENE= 
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bta OCA], [http://www.ebi.ac.uk/pdbsum/3bta PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bta RCSB]</span>
}}

'''CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A'''


==Overview==
Botulinum neurotoxin type A (BoNT/A) is the potent disease agent in botulism, a potential biological weapon and an effective therapeutic drug for involuntary muscle disorders. The crystal structure of the entire 1,285 amino acid di-chain neurotoxin was determined at 3.3 A resolution. The structure reveals that the translocation domain contains a central pair of alpha-helices 105 A long and a approximately 50 residue loop or belt that wraps around the catalytic domain. This belt partially occludes a large channel leading to a buried, negative active site--a feature that calls for radically different inhibitor design strategies from those currently used. The fold of the translocation domain suggests a mechanism of pore formation different from other toxins. Lastly, the toxin appears as a hybrid of varied structural motifs and suggests a modular assembly of functional subunits to yield pathogenesis.

==About this Structure==
3BTA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BTA OCA]. 

==Reference==
Crystal structure of botulinum neurotoxin type A and implications for toxicity., Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC, Nat Struct Biol. 1998 Oct;5(10):898-902. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9783750 9783750]
[[Category: Bontoxilysin]]
[[Category: Clostridium botulinum]]
[[Category: Single protein]]
[[Category: Lacy, D B.]]
[[Category: Stevens, R C.]]
[[Category: neurotoxin]]
[[Category: sugar binding protein]]
[[Category: translocation]]
[[Category: zinc protease]]

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