View source for 5ynn


==Crystal structure of MERS-CoV nsp16/nsp10complex bound to sinefungin and m7GpppG==
<StructureSection load='5ynn' size='340' side='right' caption='[[5ynn]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ynn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YNN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTG:7-METHYL-GUANOSINE-5-TRIPHOSPHATE-5-GUANOSINE'>GTG</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ynn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ynn OCA], [http://pdbe.org/5ynn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ynn RCSB], [http://www.ebi.ac.uk/pdbsum/5ynn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ynn ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/K4LC41_9BETC K4LC41_9BETC]] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity).[SAAS:SAAS014829_004_014545]  Nsp9 is a ssRNA-binding protein (By similarity).[SAAS:SAAS014829_004_001449] 
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</StructureSection>
[[Category: Fan, C P]]
[[Category: Guo, D Y]]
[[Category: Ke, Z H]]
[[Category: Wei, S M]]
[[Category: Yang, L]]
[[Category: Complex]]
[[Category: Inhibitor]]
[[Category: Transferase]]