View source for 3deb


==Crystal Structure of apo form (Zinc removed) of the Botulinum Neurotoxin Type C Light Chain==
<StructureSection load='3deb' size='340' side='right' caption='[[3deb]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3deb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DEB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qn0|2qn0]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BoNT/C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3deb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3deb OCA], [http://pdbe.org/3deb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3deb RCSB], [http://www.ebi.ac.uk/pdbsum/3deb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3deb ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BXC1_CLOBO BXC1_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves syntaxin. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/3deb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3deb ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Botulinum neurotoxin|Botulinum neurotoxin]]
__TOC__
</StructureSection>
[[Category: Bacillus botulinus van ermengem 1896]]
[[Category: Bontoxilysin]]
[[Category: Kumaran, D]]
[[Category: Rawat, R]]
[[Category: Swaminathan, S]]
[[Category: Apo form]]
[[Category: Botulinum neurotoxin]]
[[Category: Botulism]]
[[Category: Hydrolase]]
[[Category: Light chain]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Metalloprotease]]
[[Category: Neurotoxin]]
[[Category: Protease]]
[[Category: Secreted]]
[[Category: Snare protein]]
[[Category: Toxin]]
[[Category: Transmembrane]]
[[Category: Zinc]]