View source for 2vex

[[Image:2vex.jpg|left|200px]]

 {{Structure
|PDB= 2vex |SIZE=350|CAPTION= <scene name='initialview01'>2vex</scene>, resolution 2.2&Aring;
|SITE= <scene name='pdbsite=AC1:Iz4+Binding+Site+For+Chain+A'>AC1</scene> and <scene name='pdbsite=AC2:Mg+Binding+Site+For+Chain+A'>AC2</scene>
|LIGAND= <scene name='pdbligand=IZ4:N-{(1S)-2-{4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}-1-[(4R)-4-(2-PHENYLETHYL)-4,5-DIHYDRO-1H-IMIDAZOL-2-YL]ETHYL}-3-FLUOROBENZENESULFONAMIDE'>IZ4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
|GENE= 
|DOMAIN=
|RELATEDENTRY=[[2f6t|2F6T]], [[2f6f|2F6F]], [[2cnf|2CNF]], [[2cm3|2CM3]], [[2cm2|2CM2]], [[1g1f|1G1F]], [[1q6n|1Q6N]], [[1ptu|1PTU]], [[1c84|1C84]], [[2veu|2VEU]], [[1q1m|1Q1M]], [[1nz7|1NZ7]], [[2azr|2AZR]], [[1c88|1C88]], [[1oet|1OET]], [[1c83|1C83]], [[1sug|1SUG]], [[1onz|1ONZ]], [[1ptv|1PTV]], [[2cnh|2CNH]], [[1xbo|1XBO]], [[1g1g|1G1G]], [[2hnp|2HNP]], [[1t49|1T49]], [[1nwl|1NWL]], [[2f6y|2F6Y]], [[2cne|2CNE]], [[1nl9|1NL9]], [[1c86|1C86]], [[1kav|1KAV]], [[2hnq|2HNQ]], [[1jf7|1JF7]], [[1pxh|1PXH]], [[1q6s|1Q6S]], [[1l8g|1L8G]], [[2cma|2CMA]], [[1q6m|1Q6M]], [[1i57|1I57]], [[1bzj|1BZJ]], [[1wax|1WAX]], [[1ony|1ONY]], [[1g1h|1G1H]], [[2cng|2CNG]], [[1t4j|1T4J]], [[1kak|1KAK]], [[2cni|2CNI]], [[2b07|2B07]], [[2cm8|2CM8]], [[1eeo|1EEO]], [[1ptt|1PTT]], [[1g7g|1G7G]], [[1qxk|1QXK]], [[1ecv|1ECV]], [[1oem|1OEM]], [[2cmb|2CMB]], [[1nwe|1NWE]], [[2fjn|2FJN]], [[1aax|1AAX]], [[2vev|2VEV]], [[2vey|2VEY]], [[2b4s|2B4S]], [[2bgd|2BGD]], [[2cm7|2CM7]], [[1a5y|1A5Y]], [[2cmc|2CMC]], [[1c85|1C85]], [[1lqf|1LQF]], [[1c87|1C87]], [[2f6w|2F6W]], [[1no6|1NO6]], [[1pyn|1PYN]], [[2bge|2BGE]], [[1oes|1OES]], [[1bzc|1BZC]], [[2f6z|2F6Z]], [[2f71|2F71]], [[1q6t|1Q6T]], [[1oeu|1OEU]], [[1g7f|1G7F]], [[1nny|1NNY]], [[1q6j|1Q6J]], [[2f70|2F70]], [[1q6p|1Q6P]], [[2f6v|2F6V]], [[1t48|1T48]], [[2fjm|2FJM]], [[1oeo|1OEO]], [[1pa1|1PA1]], [[1ph0|1PH0]], [[1bzh|1BZH]], [[1gfy|1GFY]], [[1een|1EEN]], [[1pty|1PTY]], [[1oev|1OEV]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vex OCA], [http://www.ebi.ac.uk/pdbsum/2vex PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vex RCSB]</span>
}}

'''CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR'''


==Overview==
The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors of PTP1B containing imidazoles and imidazolines and their modification to interact with the B site of PTP1B are described here. The X-ray crystal structures of 3I and 4I complexed with PTP1B were solved and revealed the inhibitors are interacting extensively with the B site of the enzyme.

==About this Structure==
2VEX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEX OCA]. 

==Reference==
Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines., Douty B, Wayland B, Ala PJ, Bower MJ, Pruitt J, Bostrom L, Wei M, Klabe R, Gonneville L, Wynn R, Burn TC, Liu PC, Combs AP, Yue EW, Bioorg Med Chem Lett. 2008 Jan 1;18(1):66-71. Epub 2007 Nov 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18037290 18037290]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Single protein]]
[[Category: Ala, P J.]]
[[Category: Bostrom, L.]]
[[Category: Bower, M J.]]
[[Category: Burn, T C.]]
[[Category: Combs, A P.]]
[[Category: Douty, B.]]
[[Category: Gonneville, L.]]
[[Category: Klabe, R.]]
[[Category: Liu, P C.C.]]
[[Category: Pruitt, J.]]
[[Category: Wayland, B.]]
[[Category: Wei, M.]]
[[Category: Wynn, R.]]
[[Category: Yue, E W.]]
[[Category: acetylation]]
[[Category: endoplasmic reticulum]]
[[Category: hydrolase]]
[[Category: membrane]]
[[Category: oxidation]]
[[Category: phosphatase]]
[[Category: phosphorylation]]
[[Category: polymorphism]]
[[Category: protein phosphatase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:11:28 2008''