View source for 6ctf


==Crystal structure of GltPh fast mutant - R276S/M395R==
<StructureSection load='6ctf' size='340' side='right' caption='[[6ctf]], [[Resolution|resolution]] 4.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ctf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CTF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ctf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ctf OCA], [http://pdbe.org/6ctf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ctf RCSB], [http://www.ebi.ac.uk/pdbsum/6ctf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ctf ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GLT_PYRHO GLT_PYRHO]] Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583).<ref>PMID:17230192</ref> <ref>PMID:17435767</ref> <ref>PMID:19380583</ref> [PDB:4P19] 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Boudker, O]]
[[Category: Oh, S]]
[[Category: Ligand-bound]]
[[Category: Membrane protein]]
[[Category: Transporter]]