View source for UV excision repair protein

<StructureSection load='2qsf' size='350' side='right' caption='Structure of yeast Rad23 (green) complex with Rad4 (grey) (PDB entry [[2qsf]])' scene=''>

== Function ==

'''UV excision repair protein''' (Rad23) is a yeast protein involved in nucleotide excision repair.  The human homologs are '''hHR23A''' and '''hHR23B'''. hHR23A plays a role in translocating polyubiquitinated proteins to the proteasome.

== Structural highlights ==

The protein contains a modular domain structure consisting of ubiquitin-like domain, ubiquitin-associated domain and XPC(xeroderma pigmentosum group C protein)-binding domain<ref>PMID:21047872</ref>.

</StructureSection>
== 3D Structures of deaminase ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|

*Rad23

**[[2nbu]] – yRad23 UBA domain – yeast - NMR<br />
**[[2qsf]] – yRad23 + Rad4 <br />
**[[2qsg]], [[2qsh]], [[4yir]] – yRad23 + Rad4 + DNA <br />
**[[1x3w]], [[3esw]] – yRad23 XPC-binding domain + peptide:N-glycanase<br />
**[[1x3z]] – yRad23 XPC-binding domain + peptide:N-glycanase + peptide<br />
**[[2nbw]] – yRad23 UBA domain + RPN1 - NMR<br />
**[[3m62]] – yRad23 UBA domain + Ufd2 <br />

*Rad23 homolog hHR23 A; Domians: UBA 156-204; XPC-binding 223-317

**[[1oqy]], [[1qze]] – hHR23A – human - NMR<br />
**[[1f4i]] – hHR23A C-terminal domain (mutant) - NMR<br />
**[[1ify]] – hHR23A internal UBA domain - NMR<br />
**[[5xbo]] – hHR23A internal UBA domain + ubiquitin - NMR<br />
**[[1p98]], [[2wyq]] – hHR23A UBA domain - NMR<br />
**[[1p9d]] – hHR23A UBA domain + S5a - NMR<br />
**[[5xbo]] – hHR23A UBA domain + ubiquitin - NMR<br />
**[[1tp4]] – hHR23A XPC-binding domain - NMR<br />

*Rad23 homolog hHR23 B

**[[1p1a]] – hHR23B UBA domain - NMR<br />
**[[1pve]] – hHR23B XPC-binding domain - NMR<br />
**[[1uel]] – hHR23B UBA domain + S5a - NMR<br />
**[[1x3w]], [[2f4m]] – HR23B XPC-binding domain + peptide:N-glycanase - mouse<br />
}}
== References ==
<references/>
[[Category:Topic Page]]