View source for 2pzx

[[Image:2pzx.jpg|left|200px]]

 {{Structure
|PDB= 2pzx |SIZE=350|CAPTION= <scene name='initialview01'>2pzx</scene>, resolution 3.50&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= mth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
|DOMAIN=
|RELATEDENTRY=[[1fjr|1FJR]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pzx OCA], [http://www.ebi.ac.uk/pdbsum/2pzx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pzx RCSB]</span>
}}

'''Structure of the methuselah ectodomain with peptide inhibitor'''


==Overview==
G protein-coupled receptors (GPCRs) mediate signaling from extracellular ligands to intracellular signal transduction proteins. Methuselah (Mth) is a class B (secretin-like) GPCR, a family typified by their large, ligand-binding, N-terminal extracellular domains. Downregulation of mth increases the life span of Drosophila melanogaster; inhibitors of Mth signaling should therefore enhance longevity. We used mRNA display selection to identify high-affinity (K(d) = 15 to 30 nM) peptide ligands that bind to the N-terminal ectodomain of Mth. The selected peptides are potent antagonists of Mth signaling, and structural studies suggest that they perturb the interface between the Mth ecto- and transmembrane domains. Flies constitutively expressing a Mth antagonist peptide have a robust life span extension, which suggests that the peptides inhibit Mth signaling in vivo. Our work thus provides new life span-extending ligands for a metazoan and a general approach for the design of modulators of this important class of GPCRs.

==About this Structure==
2PZX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PZX OCA]. 

==Reference==
Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor., Ja WW, West AP Jr, Delker SL, Bjorkman PJ, Benzer S, Roberts RW, Nat Chem Biol. 2007 Jul;3(7):415-9. Epub 2007 Jun 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17546039 17546039]
[[Category: Drosophila melanogaster]]
[[Category: Single protein]]
[[Category: Benzer, S.]]
[[Category: Bjorkman, P J.]]
[[Category: Delker, S L.]]
[[Category: Ja, W W.]]
[[Category: Jr., A P.West.]]
[[Category: Roberts, R W.]]
[[Category: gpcr g protein-coupled receptor ectodomain]]
[[Category: signaling protein]]

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