View source for 2uv7


==Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP==
<StructureSection load='2uv7' size='340' side='right' caption='[[2uv7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2uv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UV7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uv4|2uv4]], [[2uv5|2uv5]], [[2uv6|2uv6]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uv7 OCA], [http://pdbe.org/2uv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uv7 RCSB], [http://www.ebi.ac.uk/pdbsum/2uv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uv7 ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uv7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uv7 ConSurf].
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit. The structure of a CBS-domain pair from human AMPK gamma1 in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.

Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.,Day P, Sharff A, Parra L, Cleasby A, Williams M, Horer S, Nar H, Redemann N, Tickle I, Yon J Acta Crystallogr D Biol Crystallogr. 2007 May;63(Pt 5):587-96. Epub 2007, Apr 21. PMID:17452784<ref>PMID:17452784</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2uv7" style="background-color:#fffaf0;"></div>

==See Also==
*[[AMP-activated protein kinase|AMP-activated protein kinase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Cleasby, A]]
[[Category: Day, P]]
[[Category: Horer, S]]
[[Category: Nar, H]]
[[Category: Parra, L]]
[[Category: Redemann, N]]
[[Category: Sharff, A]]
[[Category: Tickle, I]]
[[Category: Williams, M]]
[[Category: Yon, J]]
[[Category: Ampk gamma1 subunit cbs 3 plus 4 amp regulatory subunit. r transferase]]
[[Category: Cbs domain]]
[[Category: Fatty acid biosynthesis]]
[[Category: Lipid synthesis]]
[[Category: Transferase]]