View source for 2qvf


==mouse E-cadherin domains 1,2==
<StructureSection load='2qvf' size='340' side='right' caption='[[2qvf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2qvf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QVF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qvf OCA], [http://pdbe.org/2qvf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qvf RCSB], [http://www.ebi.ac.uk/pdbsum/2qvf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qvf ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity).  E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity). 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qv/2qvf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qvf ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Cadherin|Cadherin]]
__TOC__
</StructureSection>
[[Category: Mus musculus]]
[[Category: Carroll, K J]]
[[Category: Cadherin]]
[[Category: Calcium]]
[[Category: Cell adhesion]]
[[Category: Cell junction]]
[[Category: Cleavage on pair of basic residue]]
[[Category: E-cadherin]]
[[Category: Ecad]]
[[Category: Glycoprotein]]
[[Category: Membrane]]
[[Category: Phosphorylation]]
[[Category: Strand swap]]
[[Category: Transmembrane]]