View source for 6heb


==Influenza A Virus N9 Neuraminidase complex with Oseltamivir (Tern).==
<StructureSection load='6heb' size='340' side='right' caption='[[6heb]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6heb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I75a5 I75a5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HEB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6heb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6heb OCA], [http://pdbe.org/6heb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6heb RCSB], [http://www.ebi.ac.uk/pdbsum/6heb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6heb ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NRAM_I75A5 NRAM_I75A5]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication. 
__TOC__
</StructureSection>
[[Category: Exo-alpha-sialidase]]
[[Category: I75a5]]
[[Category: Garman, E F]]
[[Category: Hobbs, J R]]
[[Category: Kuhn, P]]
[[Category: Laver, W G]]
[[Category: Murray, J W]]
[[Category: Salinger, M T]]
[[Category: Complex]]
[[Category: Enzyme]]
[[Category: Gs4071]]
[[Category: Hydrolase]]
[[Category: Influenza]]
[[Category: Inhibitor]]
[[Category: N9]]
[[Category: Neuraminidase]]
[[Category: Oseltamivir]]
[[Category: Tamiflu]]
[[Category: Virus]]