View source for 5yb1


==Structure and function of human serum albumin-metal agent complex==
<StructureSection load='5yb1' size='340' side='right' caption='[[5yb1]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5yb1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YB1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8ZR:~{N},~{N},12-trimethyl-3$l^{3}-thia-1$l^{4},5,6$l^{4}-triaza-2$l^{3}-cupratricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,6,9,11-pentaen-4-amine'>8ZR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yb1 OCA], [http://pdbe.org/5yb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yb1 RCSB], [http://www.ebi.ac.uk/pdbsum/5yb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yb1 ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>  
== Function ==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gou, Y]]
[[Category: Wang, J]]
[[Category: Wang, T]]
[[Category: Yang, F]]
[[Category: Zhang, Z L]]
[[Category: Albumin]]
[[Category: Drug carrier]]
[[Category: Lipid binding protein]]
[[Category: Metal complex]]
[[Category: Pro-drug]]
[[Category: Target therapy]]