View source for 2bks

[[Image:2bks.gif|left|200px]]<br />
<applet load="2bks" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2bks, resolution 2.2&Aring;" />
'''CRYSTAL STRUCTURE OF RENIN-PF00074777 COMPLEX'''<br />

==Overview==
We have found that both enantiomeric configurations of the, 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin, inhibition activity and similar SAR patterns. This enantiomeric, flexibility is in contrast to a previously reported, 3-alkoxymethyl-4-arylpiperidine scaffold.

==About this Structure==
2BKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PZ1 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BKS OCA]. 

==Reference==
Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15837327 15837327]
[[Category: Homo sapiens]]
[[Category: Renin]]
[[Category: Single protein]]
[[Category: Bryant, J.W.]]
[[Category: Clay, E.H.]]
[[Category: Edmunds, J.J.]]
[[Category: Holsworth, D.D.]]
[[Category: Jalaie, M.]]
[[Category: Powell, N.A.]]
[[Category: Ryan, J.M.]]
[[Category: Zhang, E.]]
[[Category: PZ1]]
[[Category: aspartic proteinase]]
[[Category: aspartyl protease]]
[[Category: glycoprotein]]
[[Category: hydrolase]]
[[Category: plasma]]
[[Category: polymorphism]]
[[Category: signal]]
[[Category: zymogen]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 17:41:44 2007''