View source for 2lf6


==Solution NMR structure of HopABPph1448_220_320 from Pseudomonas syringae pv. phaseolicola str. 1448A, Midwest Center for Structural Genomics target APC40132.4 and Northeast Structural Genomics Consortium target PsT3A==
<StructureSection load='2lf6' size='340' side='right' caption='[[2lf6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lf6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pse14 Pse14]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LF6 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hopAB1, virPphA, PSPPH_A0127 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264730 PSE14])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf6 OCA], [http://pdbe.org/2lf6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lf6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lf6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lf6 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HPAB1_PSE14 HPAB1_PSE14]] Effector protein that plays different roles depending on the species and plant cultivars that interact with the pathogen. Acts as a virulence determinant by enhancing the development of disease symptoms and bacterial growth. Acts as an avirulence factor by eliciting hypersensitive response (HR) and plant resistance (By similarity). 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
HopPmaL is a member of the HopAB family of type III effectors present in the phytopathogen Pseudomonas syringae. Using both X-ray crystallography and solution nuclear magnetic resonance, we demonstrate that HopPmaL contains two structurally homologous yet functionally distinct domains. The N-terminal domain corresponds to the previously described Pto-binding domain, while the previously uncharacterised C-terminal domain spans residues 308-385. While structurally similar, these domains do not share significant sequence similarity and most importantly demonstrate significant differences in key residues involved in host protein recognition, suggesting that each of them targets a different host protein.

Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors.,Singer AU, Wu B, Yee A, Houliston S, Xu X, Cui H, Skarina T, Garcia M, Semesi A, Arrowsmith CH, Savchenko A Biochemistry. 2012 Jan 10;51(1):1-3. Epub 2011 Dec 28. PMID:22191472<ref>PMID:22191472</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2lf6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Pse14]]
[[Category: Arrowsmith, C H]]
[[Category: Garcia, M]]
[[Category: Houliston, S]]
[[Category: Joachimiak, A]]
[[Category: Structural genomic]]
[[Category: Montelione, G T]]
[[Category: OCSP, Ontario Centre for Structural Proteomics]]
[[Category: Savchenko, A]]
[[Category: Semesi, A]]
[[Category: Singer, A U]]
[[Category: Wu, B]]
[[Category: Yee, A]]
[[Category: Mcsg]]
[[Category: Nesg]]
[[Category: Ocsp]]
[[Category: Ontario centre for structural proteomic]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Signaling protein]]
[[Category: Type iii effector]]