View source for 2f10


==Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor==
<StructureSection load='2f10' size='340' side='right' caption='[[2f10]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2f10]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F10 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCZ:3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC+ACID'>BCZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1snt|1snt]], [[1so7|1so7]], [[1vcu|1vcu]], [[2f0z|2f0z]], [[2f11|2f11]], [[2f12|2f12]], [[2f13|2f13]], [[2f24|2f24]], [[2f25|2f25]], [[2f26|2f26]], [[2f27|2f27]], [[2f28|2f28]], [[2f29|2f29]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f10 OCA], [http://pdbe.org/2f10 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f10 RCSB], [http://www.ebi.ac.uk/pdbsum/2f10 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f10 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN]] Hydrolyzes sialylated compounds. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f10_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f10 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Neuraminidase|Neuraminidase]]
__TOC__
</StructureSection>
[[Category: Exo-alpha-sialidase]]
[[Category: Human]]
[[Category: Chavas, L M.G]]
[[Category: Colman, P M]]
[[Category: Fusi, P]]
[[Category: Kato, R]]
[[Category: McKimm-Breschkin, J]]
[[Category: Monti, E]]
[[Category: Tettamanti, G]]
[[Category: Tringali, C]]
[[Category: Venerando, B]]
[[Category: Wakatsuki, S]]
[[Category: Hydrolase]]
[[Category: Influenza virus]]
[[Category: Neuraminidase]]
[[Category: Peramivir]]
[[Category: Sialidase]]