View source for 5o6z


==17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal quinoline based inhibitor==
<StructureSection load='5o6z' size='340' side='right' caption='[[5o6z]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5o6z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O6Z FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9ME:(4-fluoranyl-3-oxidanyl-phenyl)-quinolin-2-yl-methanone'>9ME</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o6z OCA], [http://pdbe.org/5o6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o6z RCSB], [http://www.ebi.ac.uk/pdbsum/5o6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o6z ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN]] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bertoletti, N]]
[[Category: Braun, F]]
[[Category: Heine, A]]
[[Category: Klebe, G]]
[[Category: Marchais-Oberwinkler, S]]
[[Category: 17beta-hsd14]]
[[Category: Non-steroidal inhibitor]]
[[Category: Oxidoreductase]]
[[Category: Quinoline based inhibitor]]