View source for 2dk8


==Solution structure of rpc34 subunit in RNA polymerase III from mouse==
<StructureSection load='2dk8' size='340' side='right' caption='[[2dk8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DK8 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Polr3f ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dk8 OCA], [http://pdbe.org/2dk8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dk8 RCSB], [http://www.ebi.ac.uk/pdbsum/2dk8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dk8 ProSAT], [http://www.topsan.org/Proteins/RSGI/2dk8 TOPSAN]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RPC6_MOUSE RPC6_MOUSE]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/2dk8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dk8 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[RNA polymerase|RNA polymerase]]
__TOC__
</StructureSection>
[[Category: DNA-directed RNA polymerase]]
[[Category: Lk3 transgenic mice]]
[[Category: He, F]]
[[Category: Inoue, M]]
[[Category: Kigawa, T]]
[[Category: Muto, Y]]
[[Category: Structural genomic]]
[[Category: Shirouzu, M]]
[[Category: Terada, T]]
[[Category: Yokoyama, S]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rna polymerase iii c39 subunit]]
[[Category: Rna_pol_rpc34 domain]]
[[Category: Rsgi]]
[[Category: Translation]]