View source for 2irm

[[Image:2irm.gif|left|200px]]

 {{Structure
|PDB= 2irm |SIZE=350|CAPTION= <scene name='initialview01'>2irm</scene>, resolution 3.00&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00143 PP2Cc]</span>
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irm OCA], [http://www.ebi.ac.uk/pdbsum/2irm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2irm RCSB]</span>
}}

'''Crystal structure of mitogen-activated protein kinase kinase kinase 7 interacting protein 1 from Anopheles gambiae'''


==Overview==
The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

==About this Structure==
2IRM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRM OCA]. 

==Reference==
Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
[[Category: Anopheles gambiae]]
[[Category: Single protein]]
[[Category: Bonanno, J B.]]
[[Category: Burley, S K.]]
[[Category: Freeman, J C.]]
[[Category: Jin, X.]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Pelletier, L.]]
[[Category: Sauder, J M.]]
[[Category: Shapiro, L.]]
[[Category: Wasserman, S.]]
[[Category: mitogen-activated protein kinase kinase kinase 7 interacting protein 1]]
[[Category: new york structural genomix research consortium]]
[[Category: nysgxrc]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]
[[Category: tab1]]
[[Category: tak1-binding protein]]
[[Category: transferase]]

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