View source for 3hkv


==Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide==
<StructureSection load='3hkv' size='340' side='right' caption='[[3hkv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3hkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HKV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARP10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hkv OCA], [http://pdbe.org/3hkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hkv RCSB], [http://www.ebi.ac.uk/pdbsum/3hkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hkv ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PAR10_HUMAN PAR10_HUMAN]] May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.<ref>PMID:15674325</ref> <ref>PMID:16455663</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hkv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hkv ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Arrowsmith, C H]]
[[Category: Berg, S Van Den]]
[[Category: Berglund, H]]
[[Category: Bountra, C]]
[[Category: Collins, R]]
[[Category: Edwards, A M]]
[[Category: Flodin, S]]
[[Category: Flores, A]]
[[Category: Graslund, S]]
[[Category: Hammarstrom, M]]
[[Category: Johansson, A]]
[[Category: Johansson, I]]
[[Category: Karlberg, T]]
[[Category: Kotenyova, T]]
[[Category: Kotzsch, A]]
[[Category: Moche, M]]
[[Category: Nielsen, T K]]
[[Category: Nordlund, P]]
[[Category: Nyman, T]]
[[Category: Persson, C]]
[[Category: Roos, A K]]
[[Category: Structural genomic]]
[[Category: Sagemark, J]]
[[Category: Schuler, H]]
[[Category: Schutz, P]]
[[Category: Siponen, M I]]
[[Category: Thorsell, A G]]
[[Category: Tresaugues, L]]
[[Category: Weigelt, J]]
[[Category: Welin, M]]
[[Category: Wisniewska, M]]
[[Category: Cytoplasm]]
[[Category: Glycosyltransferase]]
[[Category: Nad]]
[[Category: Nucleus]]
[[Category: Parp]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Sgc]]
[[Category: Transferase]]