View source for 262d

{{Theoretical_model}}

==A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS==
<StructureSection load='262d' size='340' side='right' caption='[[262d]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=262D FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=262d FirstGlance], [http://www.ebi.ac.uk/pdbsum/262d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=262d ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Coordinated variations in the sequence of the Rev-binding element of HIV-1, identified by in vitro genetic selections, have been used as distance and conformational constraints for molecular modelling. Three-dimensional models of the wild-type Rev-binding element and several, evolved RNA ligands (aptamers) have been constructed. These models demonstrate that non-Watson-Crick pairings open the major groove allowing access of an alpha-helical peptide from Rev, and explain why some selected RNA sequences can bind Rev more tightly than others.

A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers.,Leclerc F, Cedergren R, Ellington AD Nat Struct Biol. 1994 May;1(5):293-300. PMID:7664035<ref>PMID:7664035</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 262d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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[[Category: Theoretical Model]]
[[Category: Cedergren, R J]]
[[Category: Ellington, A D]]
[[Category: Leclerc, F]]