View source for 2hts

[[Image:2hts.gif|left|200px]]

 {{Structure
|PDB= 2hts |SIZE=350|CAPTION= <scene name='initialview01'>2hts</scene>, resolution 1.83&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hts OCA], [http://www.ebi.ac.uk/pdbsum/2hts PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hts RCSB]</span>
}}

'''CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF THE HEAT SHOCK TRANSCRIPTION FACTOR'''


==Overview==
The structure of the DNA binding domain, determined at 1.8 angstrom resolution, contains a three-helix bundle that is capped by a four-stranded antiparallel beta sheet. This structure is a variant of the helix-turn-helix motif, typified by catabolite activator protein. In the heat shock transcription factor, the first helix of the motif (alpha 2) has an alpha-helical bulge and a proline-induced kink. The angle between the two helices of the motif (alpha 2 and alpha 3) is about 20 degrees smaller than the average for canonical helix-turn-helix proteins. Nevertheless, the relative positions of the first and third helices of the bundle (alpha 1 and alpha 3) are conserved. It is proposed here that the first helix of the three-helix bundle be considered a component of the helix-turn-helix motif.

==About this Structure==
2HTS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTS OCA]. 

==Reference==
Crystal structure of the DNA binding domain of the heat shock transcription factor., Harrison CJ, Bohm AA, Nelson HC, Science. 1994 Jan 14;263(5144):224-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8284672 8284672]
[[Category: Kluyveromyces lactis]]
[[Category: Single protein]]
[[Category: Harrison, C.]]
[[Category: Nelson, H.]]
[[Category: transcription factor]]

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