View source for 2hth

[[Image:2hth.jpg|left|200px]]

 {{Structure
|PDB= 2hth |SIZE=350|CAPTION= <scene name='initialview01'>2hth</scene>, resolution 2.70&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= RPS27A, UBA52, UBB, UBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|DOMAIN=
|RELATEDENTRY=[[2cay|2CAY]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hth OCA], [http://www.ebi.ac.uk/pdbsum/2hth PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hth RCSB]</span>
}}

'''Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain'''


==Overview==
The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.

==About this Structure==
2HTH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTH OCA]. 

==Reference==
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain., Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI, Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057716 17057716]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Alam, S L.]]
[[Category: Hill, C P.]]
[[Category: Sundquist, W I.]]
[[Category: Whitby, F G.]]
[[Category: glue domain]]
[[Category: ph domain]]
[[Category: protein sorting]]
[[Category: ubiquitin complex]]
[[Category: viral budding]]

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