View source for 4uey


==Structure of the periplasmic domain PhoQ double mutant (W104C-A128C)==
<StructureSection load='4uey' size='340' side='right' caption='[[4uey]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uey]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cholerae-suis"_smith_1894 "bacillus cholerae-suis" smith 1894]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UEY FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uey OCA], [http://pdbe.org/4uey PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uey RCSB], [http://www.ebi.ac.uk/pdbsum/4uey PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uey ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PHOQ_SALTY PHOQ_SALTY]] Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Essential for transcription of spiC inside macrophages by controlling the expression of the two-component regulatory system SsrB/SpiR (SsrA) and Pir at transcriptional and post-transcriptional levels respectively. Promotes expression of the two-component regulatory system PmrA/PmrB via activation of pmrD gene. Is required to attenuate bacterial growth within fibroblast cells and to enhance bacterial resistance to bile in intestinal cells. Negatively regulates prgH, which is required for invasion of epithelial cells. Involved in acid tolerance.<ref>PMID:2544889</ref> <ref>PMID:9573193</ref> <ref>PMID:15910283</ref>  

==See Also==
*[[PhoP-PhoQ|PhoP-PhoQ]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus cholerae-suis smith 1894]]
[[Category: Hicks, K G]]
[[Category: Miller, S I]]
[[Category: Sancho-Vaello, E]]
[[Category: Zeth, K]]
[[Category: Hamp domain]]
[[Category: Histidine kinase]]
[[Category: Periplasmic domain]]
[[Category: Phoq]]
[[Category: Signal transduction]]
[[Category: Signaling protein]]