View source for 5xkf


==Crystal structure of T2R-TTL-MPC6827 complex==
<StructureSection load='5xkf' size='340' side='right' caption='[[5xkf]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xkf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XKF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=88U:N-(4-methoxyphenyl)-N,2-dimethyl-quinazolin-4-amine'>88U</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xkf OCA], [http://pdbe.org/5xkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xkf RCSB], [http://www.ebi.ac.uk/pdbsum/5xkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xkf ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>  [[http://www.uniprot.org/uniprot/A0A287AGU7_PIG A0A287AGU7_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00031082] 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chen, L]]
[[Category: Wang, T]]
[[Category: Wang, Y]]
[[Category: Yang, J]]
[[Category: Colchicine binding domain]]
[[Category: Mpc-6827]]
[[Category: Structural protein]]
[[Category: Tublin]]
[[Category: Tubulin inhibitor]]