View source for 2gcv

[[Image:2gcv.gif|left|200px]]

 {{Structure
|PDB= 2gcv |SIZE=350|CAPTION= <scene name='initialview01'>2gcv</scene>, resolution 2.10&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=A23:ADENOSINE-5&#39;-PHOSPHATE-2&#39;,3&#39;-CYCLIC+PHOSPHATE'>A23</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=[[2gcs|2GCS]], [[2h0s|2H0S]], [[2h0w|2H0W]], [[2h0x|2H0X]], [[2h0z|2H0Z]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gcv OCA], [http://www.ebi.ac.uk/pdbsum/2gcv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gcv RCSB]</span>
}}

'''Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme'''


==Overview==
The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.

==About this Structure==
2GCV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCV OCA]. 

==Reference==
Structural basis of glmS ribozyme activation by glucosamine-6-phosphate., Klein DJ, Ferre-D'Amare AR, Science. 2006 Sep 22;313(5794):1752-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16990543 16990543]
[[Category: Single protein]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Klein, D J.]]
[[Category: helix]]
[[Category: pseudoknot]]
[[Category: ribozyme]]
[[Category: rna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:14:55 2008''