View source for 1udl


==The solution structure of the fifth SH3 domain of intersectin 2 (KIAA1256)==
<StructureSection load='1udl' size='340' side='right' caption='[[1udl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1udl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UDL FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh15293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1udl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udl OCA], [http://pdbe.org/1udl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1udl RCSB], [http://www.ebi.ac.uk/pdbsum/1udl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1udl ProSAT], [http://www.topsan.org/Proteins/RSGI/1udl TOPSAN]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ud/1udl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1udl ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Goroncy, A]]
[[Category: Inoue, M]]
[[Category: Kigawa, T]]
[[Category: Kobayashi, N]]
[[Category: Koshiba, S]]
[[Category: Structural genomic]]
[[Category: Tochio, N]]
[[Category: Yokoyama, S]]
[[Category: Beta barrel]]
[[Category: Endocytosis-exocytosis complex]]
[[Category: Rsgi]]
[[Category: Sh3 domain]]