View source for 6bgg


==Solution NMR structures of the BRD3 ET domain in complex with a CHD4 peptide==
<StructureSection load='6bgg' size='340' side='right' caption='[[6bgg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bgg]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BGG FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bgg OCA], [http://pdbe.org/6bgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bgg RCSB], [http://www.ebi.ac.uk/pdbsum/6bgg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bgg ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. 
== Function ==
[[http://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Blobel, G A]]
[[Category: Campbell, A E]]
[[Category: Gamsjaeger, R]]
[[Category: Kwan, A H]]
[[Category: Kwong, C]]
[[Category: Low, J K.K]]
[[Category: Lu, B]]
[[Category: Mackay, J P]]
[[Category: Silva, A P.G]]
[[Category: Szyszka, T N]]
[[Category: Vakoc, C R]]
[[Category: Wai, D C.C]]
[[Category: Wilkinson-White, L]]
[[Category: Epigenetic]]
[[Category: Protein binding]]
[[Category: Transcription regulation]]