View source for 5x86


==Crystal structure of TMP bound thymidylate kinase from thermus thermophilus HB8==
<StructureSection load='5x86' size='340' side='right' caption='[[5x86]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5x86]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X86 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X86 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x8a|5x8a]], [[5x8b|5x8b]], [[5x8c|5x8c]], [[5x8d|5x8d]], [[5x8j|5x8j]], [[5x8k|5x8k]], [[5x8v|5x8v]], [[5x98|5x98]], [[5x99|5x99]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x86 OCA], [http://pdbe.org/5x86 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x86 RCSB], [http://www.ebi.ac.uk/pdbsum/5x86 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x86 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KTHY_THET8 KTHY_THET8]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. 
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</StructureSection>
[[Category: DTMP kinase]]
[[Category: Chaudhary, S K]]
[[Category: Jeyakanthan, J]]
[[Category: Sekar, K]]
[[Category: Nucleotide monophosphate kinase]]
[[Category: Transferase]]