View source for 2ffh

[[Image:2ffh.gif|left|200px]]

 {{Structure
|PDB= 2ffh |SIZE=350|CAPTION= <scene name='initialview01'>2ffh</scene>, resolution 3.2&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=[[1ffh|1FFH]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffh OCA], [http://www.ebi.ac.uk/pdbsum/2ffh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ffh RCSB]</span>
}}

'''THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS'''


==Overview==
The crystal structure of the signal sequence binding subunit of the signal recognition particle (SRP) from Thermus aquaticus reveals a deep groove bounded by a flexible loop and lined with side chains of conserved hydrophobic residues. The groove defines a flexible, hydrophobic environment that is likely to contribute to the structural plasticity necessary for SRP to bind signal sequences of different lengths and amino acid sequence. The structure also reveals a helix-turn-helix motif containing an arginine-rich alpha helix that is required for binding to SRP RNA and is implicated in forming the core of an extended RNA binding surface.

==About this Structure==
2FFH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFH OCA]. 

==Reference==
Crystal structure of the signal sequence binding subunit of the signal recognition particle., Keenan RJ, Freymann DM, Walter P, Stroud RM, Cell. 1998 Jul 24;94(2):181-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9695947 9695947]
[[Category: Single protein]]
[[Category: Thermus aquaticus]]
[[Category: Freymann, D M.]]
[[Category: Keenan, R J.]]
[[Category: Stroud, R M.]]
[[Category: Walter, P.]]
[[Category: ffh]]
[[Category: gtpase]]
[[Category: helix-turn-helix]]
[[Category: m domain]]
[[Category: protein targeting]]
[[Category: rna-binding]]
[[Category: signal recognition particle]]
[[Category: signal sequence-binding]]
[[Category: srp54]]

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