View source for Apoptotic protease-activating factor

<StructureSection load='5juy' size='340' side='right' caption='Human apoptosis protease-activating factor-1 complex with cytochrome c and caspase 9 forming the apoptosome (PDB entry [[5juy]]) ' scene='77/774059/Cv/2'>


== Function ==

'''Apoptosis protease-activating factor-1''' (APAF-1) binds to cytochrome c and ATP to form the apoptosome which leads to the recruitment and activation of caspase 9 by cleaving the procaspase 9.  Caspase 9 is involved in executing the apoptosis of cells<ref>PMID:15829969</ref>.

== Disease ==

Inactivation of Apaf-1 is implicated in disease progression and chemoresistance of some malignancies<ref>PMID:15972851</ref>.

== Structural highlights ==

Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.
*<scene name='77/774059/Cv/3'>Apoptosome</scene> formed by Human apoptosis protease-activating factor-1 (green; subunits A, B, C, D, E, F, G) complex with cytochrome c (red; H, I, J, K, L, M, N) and caspase 9 (magenta; O, P, Q, R) (PDB entry [[5juy]]). 
</StructureSection>

==3D structures of apoptosis protease-activating factor-1==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} 

[[2ygs]], [[1cy5]], [[2p1h]] – hAPAF-1 CARD domain – human  <br />
[[1c15]], [[1cww]] – hAPAF-1 CARD domain – NMR  <br />
[[1z6t]] – hAPAF-1 + ADP   <br />
[[3ygs]] – hAPAF-1 CARD domain + procaspase 9  <br />
[[4rhw]], [[5wvc]] – hAPAF-1 CARD domain + caspase 9  <br />
[[3j2t]], [[3jbt]] – hAPAF-1 + cytochrome c<br />
[[5juy]], [[5wve]] – hAPAF-1 + caspase 9 + cytochrome c<br />

== References ==
<references/>
[[Category:Topic Page]]