View source for 5o38


==Human Brd2(BD2) mutant in free form==
<StructureSection load='5o38' size='340' side='right' caption='[[5o38]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5o38]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O38 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9JB:3-[(2~{R})-2-oxidanylpropoxy]-2-[[(2~{R})-2-oxidanylpropoxy]methyl]-2-[[(2~{S})-2-oxidanylpropoxy]methyl]propan-1-ol'>9JB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DQW:(2~{S})-1-[(2~{S})-2-oxidanylpropoxy]propan-2-ol'>DQW</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o38 OCA], [http://pdbe.org/5o38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o38 RCSB], [http://www.ebi.ac.uk/pdbsum/5o38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o38 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>  
== References ==
<references/>
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</StructureSection>
[[Category: Chan, K H]]
[[Category: Ciulli, A]]
[[Category: Runcie, A C]]
[[Category: Transcription]]