View source for 4fqv


==Crystal structure of broadly neutralizing antibody CR9114 bound to H7 influenza hemagglutinin==
<StructureSection load='4fqv' size='340' side='right' caption='[[4fqv]], [[Resolution|resolution]] 5.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fqv]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/netherlands/219/03(h7n7)) Influenza a virus (a/netherlands/219/03(h7n7))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQV FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fnk|4fnk]], [[4fqh|4fqh]], [[4fqi|4fqi]], [[4fqj|4fqj]], [[4fqk|4fqk]], [[4fql|4fql]], [[4fqm|4fqm]], [[4fqy|4fqy]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=680693 Influenza A virus (A/Netherlands/219/03(H7N7))])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqv OCA], [http://pdbe.org/4fqv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fqv RCSB], [http://www.ebi.ac.uk/pdbsum/4fqv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqv ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/Q6VMK1_9INFA Q6VMK1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643] 
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== Publication Abstract from PubMed ==
Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a significant part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.

Highly Conserved Protective Epitopes on Influenza B Viruses.,Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin O, Sieuwerts M, Brakenhoff JP, Vogels R, Li OT, Poon LL, Peiris M, Koudstaal W, Ward AB, Wilson IA, Goudsmit J, Friesen RH Science. 2012 Aug 9. PMID:22878502<ref>PMID:22878502</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 4fqv" style="background-color:#fffaf0;"></div>

==See Also==
*[[Hemagglutinin|Hemagglutinin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Dreyfus, C]]
[[Category: Ekiert, D C]]
[[Category: Wilson, I A]]
[[Category: Immune recognition]]
[[Category: Immunoglobulin]]
[[Category: Viral fusion protein]]
[[Category: Viral protein-immune system complex]]
[[Category: Virus attachment and entry]]