View source for 5ntu


==Crystal Structure of human Pro-myostatin Precursor at 2.6 A Resolution==
<StructureSection load='5ntu' size='340' side='right' caption='[[5ntu]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ntu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NTU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ntu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ntu OCA], [http://pdbe.org/5ntu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ntu RCSB], [http://www.ebi.ac.uk/pdbsum/5ntu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ntu ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/GDF8_HUMAN GDF8_HUMAN]] Myostatin-related muscle hypertrophy. The disease is caused by mutations affecting the gene represented in this entry. 
== Function ==
[[http://www.uniprot.org/uniprot/GDF8_HUMAN GDF8_HUMAN]] Acts specifically as a negative regulator of skeletal muscle growth. 
__TOC__
</StructureSection>
[[Category: Cotton, T R]]
[[Category: Fischer, G]]
[[Category: Hyvonen, M]]
[[Category: Cystine knot]]
[[Category: Growth factor]]
[[Category: Signaling protein]]
[[Category: Signalling protein]]
[[Category: Tgfbeta family]]