View source for 1ewo


==THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204==
<StructureSection load='1ewo' size='340' side='right' caption='[[1ewo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ewo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EWO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VSC:N-[N-BENZYLOXYCARBONYL-PHENYLALANINYL]-3-AMINO-5-PHENYL-PENTANE-1-SULFONIC+ACID+PHENYL+ESTER'>VSC</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aim|1aim]], [[2aim|2aim]], [[1ewl|1ewl]], [[1ewm|1ewm]], [[1ewp|1ewp]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ewo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ewo OCA], [http://pdbe.org/1ewo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ewo RCSB], [http://www.ebi.ac.uk/pdbsum/1ewo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ewo ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.  The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/1ewo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ewo ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Trycr]]
[[Category: Brinen, L S]]
[[Category: Fletterick, R J]]
[[Category: Gillmor, S A]]
[[Category: Covalent inhibitor]]
[[Category: Cruzipain]]
[[Category: Cysteine protease]]
[[Category: Drug design]]
[[Category: Hydrolase-hydrolase inhibitor complex]]