View source for 6elm


==Crystal structure of the human WNK2 CCT1 domain==
<StructureSection load='6elm' size='340' side='right' caption='[[6elm]], [[Resolution|resolution]] 1.14&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6elm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ELM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ELM FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6elm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6elm OCA], [http://pdbe.org/6elm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6elm RCSB], [http://www.ebi.ac.uk/pdbsum/6elm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6elm ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/WNK2_HUMAN WNK2_HUMAN]] Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.<ref>PMID:17667937</ref> <ref>PMID:18593598</ref> <ref>PMID:21733846</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bufton, J C]]
[[Category: Bullock, A]]
[[Category: Burgess-Brown, N A]]
[[Category: Chalk, R]]
[[Category: Delft, F von]]
[[Category: Edwards, A M]]
[[Category: Newman, J A]]
[[Category: Pinkas, D M]]
[[Category: Ai domain]]
[[Category: Cct domain]]
[[Category: Rfxv motif binding]]
[[Category: Structural genomic]]
[[Category: Wnk2]]