View source for 6env


==X-ray structure of Au2phen-encapsulated horse spleen apoferritin==
<StructureSection load='6env' size='340' side='right' caption='[[6env]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6env]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ENV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ENV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6env FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6env OCA], [http://pdbe.org/6env PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6env RCSB], [http://www.ebi.ac.uk/pdbsum/6env PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6env ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Two anticancer gold(iii) compounds, Au2phen and Auoxo4, were encapsulated within a ferritin nanocage. The gold-compound loaded proteins were characterized by UV-Vis spectroscopy, inductively coupled plasma mass spectrometry and circular dichroism. X-ray crystallography shows that the compounds degrade upon encapsulation and gold(i) ions bind Ft within the cage, close to the side chains of Cys126. The gold-encapsulated nanocarriers are cytotoxic to human cancer cells. Au(i)-loaded Ft, obtained upon the encapsulation of Au2phen within the cage, induces oxidative stress activation, which finally leads to apoptosis in MCF-7 cells.

Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells.,Monti DM, Ferraro G, Petruk G, Maiore L, Pane F, Amoresano A, Cinellu MA, Merlino A Dalton Trans. 2017 Nov 14;46(44):15354-15362. doi: 10.1039/c7dt02370g. PMID:29072740<ref>PMID:29072740</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6env" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Equus caballus]]
[[Category: Ferraro, G]]
[[Category: Merlino, A]]
[[Category: Cytotoxicity]]
[[Category: Drug delivery]]
[[Category: Encapsulation]]
[[Category: Ferritin]]
[[Category: Gold]]
[[Category: Nanocarrier]]
[[Category: Protein transport]]