View source for 2atf

[[Image:2atf.gif|left|200px]]

 {{Structure
|PDB= 2atf |SIZE=350|CAPTION= <scene name='initialview01'>2atf</scene>, resolution 1.75&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_dioxygenase Cysteine dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.20 1.13.11.20] </span>
|GENE= Cdo1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam05995 CDO_I]</span>
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2atf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2atf OCA], [http://www.ebi.ac.uk/pdbsum/2atf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2atf RCSB]</span>
}}

'''X-RAY STRUCTURE OF cysteine dioxygenase type I FROM MUS MUSCULUS MM.241056'''


==Overview==
Cysteine dioxygenase (CDO) catalyzes the oxidation of l-cysteine to cysteine sulfinic acid. Deficiencies in this enzyme have been linked to autoimmune diseases and neurological disorders. The x-ray crystal structure of CDO from Mus musculus was solved to a nominal resolution of 1.75 Angstroms. The sequence is 91% identical to that of a human homolog. The structure reveals that CDO adopts the typical beta-barrel fold of the cupin superfamily. The NE2 atoms of His-86, -88, and -140 provide the metal binding site. The structure further revealed a covalent linkage between the side chains of Cys-93 and Tyr-157, the cysteine of which is conserved only in eukaryotic proteins. Metal analysis showed that the recombinant enzyme contained a mixture of iron, nickel, and zinc, with increased iron content associated with increased catalytic activity. Details of the predicted active site are used to present and discuss a plausible mechanism of action for the enzyme.

==About this Structure==
2ATF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATF OCA]. 

==Reference==
Structure and mechanism of mouse cysteine dioxygenase., McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN Jr, Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3084-9. Epub 2006 Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16492780 16492780]
[[Category: Cysteine dioxygenase]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Allard, S T.M.]]
[[Category: Bingman, C A.]]
[[Category: Bitto, E.]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Jr., G N.Phillips.]]
[[Category: Mccoy, J G.]]
[[Category: Wesenberg, G E.]]
[[Category: bc013638]]
[[Category: center for eukaryotic structural genomic]]
[[Category: cesg]]
[[Category: cupin family]]
[[Category: mm 241056]]
[[Category: pfam05995 2 cdo_i]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]

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