View source for 5ile


==H64A sperm whale myoglobin with a Fe-tolyl moiety==
<StructureSection load='5ile' size='340' side='right' caption='[[5ile]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ile]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Phycd Phycd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ILE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ILE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6CQ:[3,3-(7,12-DIETHENYL-3,8,13,17-TETRAMETHYLPORPHYRIN-2,18-DIYL-KAPPA~4~N~21~,N~22~,N~23~,N~24~)DI(PROPANOATO)(2-)](3-METHYLPHENYL)IRON'>6CQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5iks|5iks]], [[5ilp|5ilp]], [[5ilr|5ilr]], [[5ilm|5ilm]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9755 PHYCD])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ile FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ile OCA], [http://pdbe.org/5ile PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ile RCSB], [http://www.ebi.ac.uk/pdbsum/5ile PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ile ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MYG_PHYCD MYG_PHYCD]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bioorganometallic Fe-C bonds are biologically relevant species that may result from the metabolism of natural or synthetic hydrazines. The molecular structures of four new sperm whale mutant myoglobin derivatives with Fe-aryl moieties, namely H64A-tolyl-m, H64A-chlorophenyl-p, H64Q-tolyl-m, and H64Q-chlorophenyl-p, have been determined at 1.7-1.9A resolution. The structures reveal conformational preferences for the substituted aryls resulting from attachment of the aryl ligands to Fe at the site of net -NHNH2 release from the precursor hydrazines, and show distal pocket changes that readily accommodate these bulky ligands.

Organometallic myoglobins: Formation of Fe-carbon bonds and distal pocket effects on aryl ligand conformations.,Wang B, Thomas LM, Richter-Addo GB J Inorg Biochem. 2016 Jun 24. pii: S0162-0134(16)30192-1. doi:, 10.1016/j.jinorgbio.2016.06.028. PMID:27687333<ref>PMID:27687333</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5ile" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Phycd]]
[[Category: Richter-Addo, G B]]
[[Category: Thomas, L M]]
[[Category: Wang, B]]
[[Category: 3-methylphenylhydrazine]]
[[Category: 4-chlorophenylhydrazine]]
[[Category: Arylhydrazine]]
[[Category: Bioorganometallic]]
[[Category: Heme]]
[[Category: Hydrazine]]
[[Category: Iron-carbon]]
[[Category: Meta-tolylhydrazine]]
[[Category: Oxygen transport]]
[[Category: Para-chlorophenylhydrazine]]
[[Category: Phenylhydrazine]]
[[Category: Sigma-aryl]]