View source for 1wzy

[[Image:1wzy.jpg|left|200px]]

 {{Structure
|PDB= 1wzy |SIZE=350|CAPTION= <scene name='initialview01'>1wzy</scene>, resolution 2.50&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=F29:1-ALLYL-5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE'>F29</scene>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
|GENE= 
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzy OCA], [http://www.ebi.ac.uk/pdbsum/1wzy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wzy RCSB]</span>
}}

'''Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative'''


==Overview==
A series of pyrazolopyridazine compounds were briefly investigated as ERK2 inhibitors. The crystal structure of ERK2 complexed with an allyl derivative was determined. The compound induces structural change including movement of the glycine-rich loop and peptide flip between Met108-Glu109. As a result, the newly formed subsite can recognize small hydrophobic substituents but not hydrophilic ones.

==About this Structure==
1WZY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZY OCA]. 

==Reference==
Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative., Kinoshita T, Warizaya M, Ohori M, Sato K, Neya M, Fujii T, Bioorg Med Chem Lett. 2006 Jan 1;16(1):55-8. Epub 2005 Oct 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16242327 16242327]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Single protein]]
[[Category: Kinoshita, T.]]
[[Category: erk2]]
[[Category: inhibitor]]
[[Category: kinase]]

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