View source for 1vqe

[[Image:1vqe.jpg|left|200px]]

 {{Structure
|PDB= 1vqe |SIZE=350|CAPTION= <scene name='initialview01'>1vqe</scene>, resolution 1.8&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqe OCA], [http://www.ebi.ac.uk/pdbsum/1vqe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vqe RCSB]</span>
}}

'''GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY MET 47 (V35I, I47M)'''


==Overview==
The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of single and double mutants in the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are additive when the regions structurally influenced by the mutations do not substantially overlap. These regions of influence can provide a simple basis for identifying sets of mutations that will show additive effects.

==About this Structure==
1VQE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_f1 Enterobacteria phage f1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQE OCA]. 

==Reference==
Potential use of additivity of mutational effects in simplifying protein engineering., Skinner MM, Terwilliger TC, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10753-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8855252 8855252]
[[Category: Enterobacteria phage f1]]
[[Category: Single protein]]
[[Category: Skinner, M M.]]
[[Category: Terwilliger, T C.]]
[[Category: dna-binding protein]]
[[Category: gene v]]
[[Category: mutant]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:27:18 2008''