View source for 4qu1


==Crystal structure of human JMJD5 jmj-c domain==
<StructureSection load='4qu1' size='340' side='right' caption='[[4qu1]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4qu1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QU1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uyj|3uyj]], [[4aap|4aap]], [[4gaz|4gaz]], [[4gjy|4gjy]], [[4gjz|4gjz]], [[4qsz|4qsz]], [[4qu2|4qu2]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qu1 OCA], [http://pdbe.org/4qu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qu1 RCSB], [http://www.ebi.ac.uk/pdbsum/4qu1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qu1 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. 

==See Also==
*[[Jumonji domain-containing protein|Jumonji domain-containing protein]]
__TOC__
</StructureSection>
[[Category: Liu, H L]]
[[Category: Wang, C]]
[[Category: Zhang, G Y]]
[[Category: Demethylation]]
[[Category: Jmj-c domain]]
[[Category: Oxidoreductase]]