View source for 5k7n


==MicroED structure of tau VQIVYK peptide at 1.1 A resolution==
<StructureSection load='5k7n' size='340' side='right' caption='[[5k7n]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5k7n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K7N FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5k7o|5k7o]], [[5k7p|5k7p]], [[5k7q|5k7q]], [[5k7r|5k7r]], [[5k7s|5k7s]], [[5k7t|5k7t]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k7n OCA], [http://pdbe.org/5k7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k7n RCSB], [http://www.ebi.ac.uk/pdbsum/5k7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k7n ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Traditionally, crystallographic analysis of macromolecules has depended on large, well-ordered crystals, which often require significant effort to obtain. Even sizable crystals sometimes suffer from pathologies that render them inappropriate for high-resolution structure determination. Here we show that fragmentation of large, imperfect crystals into microcrystals or nanocrystals can provide a simple path for high-resolution structure determination by the cryoEM method MicroED and potentially by serial femtosecond crystallography.

Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.,de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T Nat Methods. 2017 Feb 13;14(4):399-402. doi: 10.1038/nmeth.4178. PMID:28192420<ref>PMID:28192420</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5k7n" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cascio, D]]
[[Category: Cruz, M J.de la]]
[[Category: Eisenberg, D]]
[[Category: Gonen, T]]
[[Category: Hattne, J]]
[[Category: Reyes, F E]]
[[Category: Rodriguez, J]]
[[Category: Sawaya, M R]]
[[Category: Seidler, P]]
[[Category: Shi, D]]
[[Category: Amyloid]]
[[Category: Protein fibril]]