View source for 5kmw


==TOHO1 Beta lactamase mutant E166A/R274N/R276N -benzyl penicillin complex==
<StructureSection load='5kmw' size='340' side='right' caption='[[5kmw]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5kmw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KMW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNM:OPEN+FORM+-+PENICILLIN+G'>PNM</scene>, <scene name='pdbligand=PNN:PENICILLIN+G'>PNN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u2x|5u2x]], [[5u2y|5u2y]], [[5u2z|5u2z]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kmw OCA], [http://pdbe.org/5kmw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kmw RCSB], [http://www.ebi.ac.uk/pdbsum/5kmw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kmw ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity. 
__TOC__
</StructureSection>
[[Category: Beta-lactamase]]
[[Category: Coates, L]]
[[Category: Cooper, J B]]
[[Category: Ginell, S L]]
[[Category: Langan, P S]]
[[Category: Vandavasi, V G]]
[[Category: Weiss, K L]]
[[Category: Acyl-enzyme]]
[[Category: Class a beta-lactamase]]
[[Category: Hydrolase]]
[[Category: Substrate recognition]]