View source for 1t3b

[[Image:1t3b.gif|left|200px]]

 {{Structure
|PDB= 1t3b |SIZE=350|CAPTION= <scene name='initialview01'>1t3b</scene>, resolution 2.5&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span>
|GENE= DSBC, XPRA, HI1213 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3b OCA], [http://www.ebi.ac.uk/pdbsum/1t3b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t3b RCSB]</span>
}}

'''X-ray Structure of DsbC from Haemophilus influenzae'''


==Overview==
Bacterial DsbC proteins are involved in rearranging or reducing mismatched disulfide bonds folding within the periplasm. The X-ray structure of the enzyme from Haemophilus influenzae has been solved and compared with the known structure of the Escherichia coli protein. The proteins act as V-shaped dimers with a large cleft to accommodate substrate proteins. The dimers are anchored by a small N-terminal domain, but have a flexible linker region which allows the larger C-terminal domain, with its reactive sulfhydryls, to clamp down on substrates. The overall folds are very similar, but the comparison shows a wider range of hinge motions than previously thought. The crystal packing of the H. influenzae protein allows the movement of the N-terminal domain with respect to the C-terminal domain through motions in the flexible hinge, generating high thermal parameters and unusually high anisotropy in the crystallographic data.

==About this Structure==
1T3B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3B OCA]. 

==Reference==
Structure of DsbC from Haemophilus influenzae., Zhang M, Monzingo AF, Segatori L, Georgiou G, Robertus JD, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1512-8. Epub 2004, Aug 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15333920 15333920]
[[Category: Haemophilus influenzae]]
[[Category: Protein disulfide-isomerase]]
[[Category: Single protein]]
[[Category: Georgiou, G.]]
[[Category: Monzingo, A F.]]
[[Category: Robertus, J D.]]
[[Category: Segatori, L.]]
[[Category: Zhang, M.]]
[[Category: oxidoreductase]]
[[Category: protein disulfide isomerase]]
[[Category: protein folding]]
[[Category: redox protein]]
[[Category: redox-active center]]

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