View source for 4jqh


==Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain==
<StructureSection load='4jqh' size='340' side='right' caption='[[4jqh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jqh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_7120 Anabaena 7120]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JQH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MF:4-{[(4-CARBOXYBUTYL)(2-{2-[(4-PHENOXYBIPHENYL-4-YL)METHOXY]PHENYL}ETHYL)AMINO]METHYL}BENZOIC+ACID'>1MF</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l6j|3l6j]], [[4iae|4iae]], [[4iah|4iah]], [[4iam|4iam]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">alr2278 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=103690 Anabaena 7120])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_cyclase Guanylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.2 4.6.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jqh OCA], [http://pdbe.org/4jqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jqh RCSB], [http://www.ebi.ac.uk/pdbsum/4jqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jqh ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Recently, the structure of BAY 58-2667 bound to the Nostoc sp. H-NOX domain was published. On the basis of this structural information, we designed BAY 58-2667 derivatives and tested their effects on soluble guanylyl cyclase (sGC) activity. Derivative 20 activated sGC 4.8-fold more than BAY 58-2667. Co-crystallization of 20 with the Ns H-NOX domain revealed that the increased conformational distortion at the C-terminal region of alphaF helix containing 110-114 residues contributes to the higher activation triggered by 20.

Insights into Soluble Guanylyl Cyclase Activation Derived from Improved Heme-Mimetics.,von Wantoch Rekowski M, Kumar V, Zhou Z, Moschner J, Marazioti A, Bantzi M, Spyroulias GA, van den Akker F, Giannis A, Papapetropoulos A J Med Chem. 2013 Oct 24. PMID:24090476<ref>PMID:24090476</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4jqh" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Anabaena 7120]]
[[Category: Guanylate cyclase]]
[[Category: Akker, F van den]]
[[Category: Kumar, V]]
[[Category: Analogue of bay58-2667]]
[[Category: Guanylyl cyclase]]
[[Category: Signaling protein]]