View source for 2mit


==Solution structure of oxidized dimeric form of human defensin 5==
<StructureSection load='2mit' size='340' side='right' caption='[[2mit]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mit]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIT FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2lxz|2lxz]], [[1zmp|1zmp]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mit OCA], [http://pdbe.org/2mit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mit RCSB], [http://www.ebi.ac.uk/pdbsum/2mit PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mit ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN]] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref>  

==See Also==
*[[Defensin|Defensin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Nolan, E M]]
[[Category: Wagner, G]]
[[Category: Wommack, A J]]
[[Category: Ziarek, J J]]
[[Category: Antimicrobial peptide]]
[[Category: Antimicrobial protein]]
[[Category: Cysteine knot]]