View source for 2mka


==Spatial structure of the Toll-like receptor 3 transmembrane domain in the trimeric state==
<StructureSection load='2mka' size='340' side='right' caption='[[2mka]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mka]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKA FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mk9|2mk9]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mka OCA], [http://pdbe.org/2mka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mka RCSB], [http://www.ebi.ac.uk/pdbsum/2mka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mka ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/TLR3_HUMAN TLR3_HUMAN]] Defects in TLR3 are associated with herpes simplex encephalitis type 2 (HSE2) [MIM:[http://omim.org/entry/613002 613002]]. HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Note=TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.<ref>PMID:17872438</ref>  
== Function ==
[[http://www.uniprot.org/uniprot/TLR3_HUMAN TLR3_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:16144834</ref> <ref>PMID:16858407</ref> <ref>PMID:16720699</ref> <ref>PMID:17178723</ref> <ref>PMID:18172197</ref> <ref>PMID:16043704</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Toll-like receptors (TLRs) take part in both the innate and adaptive immune systems. The role of the transmembrane domain in TLR signaling is still elusive, while its importance for the TLR activation was clearly demonstrated. In the present study the ability of the TLR3 transmembrane domain to form dimers and trimers in detergent micelles was shown by solution NMR spectroscopy. Spatial structures and free energy magnitudes were determined for the TLR3 transmembrane domain in dimeric and trimeric states, and two possible surfaces that may be used for the helix-helix interaction by the full-length TLR3 were revealed.

Toll-like receptor 3 transmembrane domain is able to perform various homotypic interactions: An NMR structural study.,Mineev KS, Goncharuk SA, Arseniev AS FEBS Lett. 2014 Sep 12. pii: S0014-5793(14)00658-9. doi:, 10.1016/j.febslet.2014.08.031. PMID:25217833<ref>PMID:25217833</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mka" style="background-color:#fffaf0;"></div>

==See Also==
*[[Toll-like Receptors|Toll-like Receptors]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arseniev, A S]]
[[Category: Gonscharuk, S A]]
[[Category: Mineev, K]]
[[Category: Immune system]]
[[Category: Transmembrane domain]]
[[Category: Trimer]]